| | Day | Time | | Opponent | Score | | | Record | |
| August |
| | 20 | 7:00 PM | vs. | Spring Arbor University | W-3-0 | stats | | 1-0 | Details |
| | 22 | 1:30 PM | vs. | Marian University | W-3-0 | stats | | 2-0 | Details |
| | Early Bird Classic -Dearborn, Mich. |
| | | 5:00 PM | @ | Trinity International University | L-1-2 (OT) | stats | | 2-1 | Details |
| | | 8:45 PM | vs. | Robert Morris College | W-3-0 | stats | | 3-1 | Details |
| | Early Bird Classic -Dearborn, Mich. |
| | 23 | 9:00 AM | vs. | Point Park University | W-3-0 | stats | | 4-1 | Details |
| | Early Bird Classic -Dearborn, Mich. |
| | | 1:00 PM | vs. | Mount Vernon Nazarene University | W-3-0 | stats | | 5-1 | Details |
| | Madonna wins 2008 UM-Dearborn Early Bird Championship |
| | | 2:00 PM | @ | Illinois Institute of Technology | W-4-0 | stats | | 6-1 | Details |
| | 24 | | @ | TBA | L-1-6 | stats | | 6-2 | Details |
| | USF Fall Invite (Hosted by St. Francis, Ind.) |
| | | | @ | TBA | L-3-4 | stats | | 6-3 | Details |
| | USF Fall Invite (Hosted by St. Francis, Ind.) |
| | 25 | | @ | TBA | L-2-6 | stats | | 6-4 | Details |
| | USF Fall Invite (Hosted by St. Francis, Ind.) |
| | | | @ | TBA | L-3-4 | stats | | 6-5 | Details |
| | USF Fall Invite (Hosted by St. Francis, Ind.) |
| | 26 | 4:00 PM | vs. | Houghton College | W-1-0 | stats | | 7-5 | Details |
| | Houghton ranked 17th in the NAIA poll |
| | 29 | 10:00 AM | @ | TBA | L-7-16 | stats | | 7-6 | Details |
| | Lou Collins Classic (Hosted by Olivet College) |
| | | 12:00 PM | vs. | Ashford University | W-3-0 | stats | | 8-6 | Details |
| | Seaside Invite - San Diego, Calif. |
| | | 6:00 PM | @ | Point Loma Nazarene University | W-2-1 (OT) | stats | | 9-6 | Details |
| | Pt. Loma ranked 16th in NAIA poll |
| | | 9:00 PM | vs. | Mount Marty College | W-3-0 | stats | | 10-6 | Details |
| | Seaside Invite - San Diego, Calif. |
| | 30 | 8:00 AM | @ | TBA | L-8-16 | stats | | 10-7 | Details |
| | Lou Collins Classic (Hosted by Olivet College) |
| | | 1:00 PM | vs. | College of Idaho | W-3-2 | stats | | 11-7 | Details |
| | C of I ranked No. 9 in NAIA Poll...Seaside Invite - San Diego, Calif. |
| | | 7:30 PM | vs. | Mid America Nazarene | W-2-1 | stats | | 12-7 | Details |
| | Game Played at Point Loma Nazarene (Calif.) |
| | | 8:00 PM | @ | Point Loma Nazarene University | L-1-3 | stats | | 12-8 | Details |
| | Point Loma ranked No. 8 in NAIA poll...Seaside Invite - San Diego, Calif. |
| September |
| | 1 | 1:00 PM | vs. | Bellevue University | L-1-2 (2OT) | stats | | 12-9 | Details |
| | Game Played at Point Loma Nazarene (Calif.) |
| | 5 | 3:00 PM | vs. | Davenport University | W-3-0 | stats | | 13-9 | Details |
| | Julie Martin Memorial Tournament - Livonia, Mich. |
| | | 4:00 PM | vs. | University of Detroit | L-0-2 | stats | | 13-10 | Details |
| | | 7:00 PM | vs. | Cedarville University | W-3-1 | stats | | 14-10 | Details |
| | Julie Martin Memorial Tournament - Livonia, Mich. |
| | 6 | | vs. | Spring Arbor University | W-3-1 | stats | | 15-10 | Details |
| | Julie Martin Memorial Tournament - Livonia, Mich. |
| | | | @ | TBA | W-127-0 | stats | | 16-10 | Details |
| | Running Fit - Tommy Titan Invite |
| | | | @ | TBA | W-127-0 | stats | | 17-10 | Details |
| | Running Fit - Tommy Titan Invite |
| | | 9:30 AM | vs. | University of Windsor | W-3-0 | stats | | 18-10 | Details |
| | Julie Martin Memorial Tournament - Livonia, Mich. |
| * | 9 | | @ | TBA | L-2-7 | stats | | 18-11 0-1 | Details |
| | WHAC Jamboree One (hosted by Indiana Tech) |
| * | | | @ | TBA | L-2-6 | stats | | 18-12 0-2 | Details |
| | WHAC Jamboree One (Hosted by Indiana Tech) |
| * | | 7:00 PM | @ | Concordia University | W-3-0 | stats | | 19-12 1-2 | Details |
| * | 12 | 4:00 PM | @ | Aquinas College | W-4-0 | stats | | 20-12 2-2 | Details |
| | Madonna RV in NAIA; conference opener |
| | | 7:30 PM | @ | Findlay University | W-3-2 | stats | | 21-12 | Details |
| | Madonna down 2-0, came back to win 3-2 |
| * | 13 | 1:00 PM | @ | Aquinas College | W-2-1 | stats | | 22-12 3-2 | Details |
| * | 16 | | @ | TBA | L-2-7 | stats | | 22-13 3-3 | Details |
| | WHAC Jamboree Three (hosted by Davenport) |
| * | | | @ | TBA | L-1-6 | stats | | 22-14 3-4 | Details |
| | WHAC Jamboree Two (Hosted by Davenport) |
| * | | 4:00 PM | @ | Concordia University | W-4-1 | stats | | 23-14 4-4 | Details |
| | Moved from MU due to poor field conditions |
| * | | 7:00 PM | @ | Aquinas College | W-3-0 | stats | | 24-14 5-4 | Details |
| | Madonna #6 in NAIA |
| * | 17 | 4:00 PM | @ | Concordia University | W-3-0 | stats | | 25-14 6-4 | Details |
| | Moved to Concordia due to poor field conditions |
| | 19 | 4:00 PM | @ | TBA | L-30-35 | stats | | 25-15 | Details |
| | National Catholic Cross Country Invitational (South Bend, Ind.) |
| | | 4:00 PM | @ | TBA | W-127-0 | stats | | 26-15 | Details |
| | National Catholic Cross Country Invitational (South Bend, Ind.) |
| * | 20 | | @ | TBA | L-2-6 | stats | | 26-16 6-5 | Details |
| | WHAC Jamboree Three (Hosted by Siena Heights) |
| * | | 12:00 PM | @ | Davenport University | W-6-2 | stats | | 27-16 7-5 | Details |
| * | | 3:00 PM | @ | Davenport University | W-4-2 | stats | | 28-16 8-5 | Details |
| * | 23 | 4:00 PM | @ | Indiana Institute of Technology | W-3-0 | stats | | 29-16 9-5 | Details |
| * | | 7:00 PM | vs. | Concordia University | W-3-0 | stats | | 30-16 10-5 | Details |
| * | 24 | 7:00 PM | @ | Indiana Institute of Technology | W-4-1 | stats | | 31-16 11-5 | Details |
| * | 25 | 7:00 PM | @ | University of Michigan-Dearborn | W-3-0 | | | 32-16 12-5 | Details |
| * | 26 | | @ | TBA | L-3-7 | stats | | 32-17 12-6 | Details |
| | WHAC Jamboree Four (hosted by Concordia) |
| * | | | @ | TBA | L-2-6 | stats | | 32-18 12-7 | Details |
| | WHAC Jamboree Four (Hosted by Concordia) |
| * | | 4:00 PM | vs. | Siena Heights University | W-1-0 (OT) | stats | | 33-18 13-7 | Details |
| | | 4:00 PM | @ | TBA | L-11-19 | stats | | 33-19 | Details |
| | Lansing Invite (Grand Woods Park) |
| | | 4:00 PM | @ | TBA | L-6-18 | stats | | 33-20 | Details |
| | Lansing Invite (Grand Woods Park) |
| * | 27 | 9:00 AM | vs. | TBA | W-7-2 | stats | | 34-20 14-7 | Details |
| | WHAC Jamboree Five (hosted by Madonna) at Fellow's Creek GC in Canton |
| * | | 12:00 PM | vs. | TBA | W-6-1 | stats | | 35-20 15-7 | Details |
| | WHAC Jamboree Five (Hosted by Madonna) at Hill Top GC in Plymouth |
| * | | 1:00 PM | vs. | Siena Heights University | W-2-1 | stats | | 36-20 16-7 | Details |
| | 29 | | @ | TBA | L-4-7 | stats | | 36-21 | Details |
| | WHAC Jamboree Two Make-up at Siena Heights |
| | 30 | 4:00 PM | @ | Spring Arbor University | RAIN | | | | Details |
| * | | 7:00 PM | @ | Siena Heights University | W-3-0 | stats | | 37-21 17-7 | Details |
| October |
| * | 2 | 7:00 PM | vs. | Cornerstone University | W-3-1 | stats | | 38-21 18-7 | Details |
| * | 3 | | @ | TBA | L-4-7 | stats | | 38-22 18-8 | Details |
| | WHAC Jamboree Six (hosted by Cornerstone) |
| * | | | @ | TBA | L-1-6 | stats | | 38-23 18-9 | Details |
| | WHAC Jamboree Six (Hosted by Cornerstone) |
| | | 2:00 PM | @ | TBA | T-7-7 | stats | | 38-23-1 | Details |
| | Great Lakes Region Invite (Lenawee Christian HS) |
| | | 2:00 PM | @ | TBA | L-6-9 | stats | | 38-24-1 | Details |
| | Great Lakes Region Invite (Lenawee Christian HS) |
| * | 4 | 12:00 PM | @ | Cornerstone University | W-3-0 | | | 39-24-1 19-9 | Details |
| | | 12:00 PM | @ | TBA | L-2-5 | stats | | 39-25-1 | Details |
| | Siena Heights Invitational |
| * | | 2:30 PM | @ | Cornerstone University | W-2-0 | stats | | 40-25-1 20-9 | Details |
| * | 7 | 7:00 PM | vs. | Aquinas College | W-3-0 | stats | | 41-25-1 21-9 | Details |
| * | 8 | | @ | TBA | L-2-7 | stats | | 41-26-1 21-10 | Details |
| | WHAC Jamboree Seven (hosted by Aquinas) |
| * | | | @ | TBA | L-2-6 | stats | | 41-27-1 21-11 | Details |
| | WHAC Jamboree Seven (Hosted by Aquinas) |
| * | 9 | 7:00 PM | @ | Indiana Institute of Technology | PPD | | | | Details |
| | 11 | 11:30 AM | @ | TBA | L-22-28 | stats | | 41-28-1 | Details |
| | Lucian Rosa Parkside Invite (UW-Parkside) |
| | | 11:30 AM | @ | TBA | L-24-31 | stats | | 41-29-1 | Details |
| | Lucian Rosa Parkside Invite (UW-Parkside) |
| * | | 12:00 PM | vs. | Aquinas College | W-2-0 | stats | | 42-29-1 22-11 | Details |
| * | | 2:30 PM | vs. | Aquinas College | L-0-1 | stats | | 42-30-1 22-12 | Details |
| * | 14 | 4:00 PM | vs. | Concordia University | W-5-0 | stats | | 43-30-1 23-12 | Details |
| | Switched to MU after 9/16 game moved to CUAA |
| * | | 7:00 PM | vs. | Davenport University | W-3-0 | stats | | 44-30-1 24-12 | Details |
| * | 15 | 3:00 PM | vs. | Concordia University | W-3-0 | stats | | 45-30-1 25-12 | Details |
| | 17 | 4:00 PM | vs. | University of Illinois at Springfield | W-3-0 | stats | | 46-30-1 | Details |
| | Lindenwood Classic - St. Charles, Mo. |
| | | 8:00 PM | @ | Lindenwood University | L-0-3 | stats | | 46-31-1 | Details |
| | MU #6, LU #8 in NAIA Poll | Lindenwood Classic - St. Charles, Mo. |
| | 18 | 11:00 AM | vs. | Columbia College | W-3-2 | stats | | 47-31-1 | Details |
| | MU #7, CC #6 in NAIA Poll | Lindenwood Classic - St. Charles, Mo. |
| * | | 12:00 PM | vs. | Davenport University | W-4-0 | stats | | 48-31-1 26-12 | Details |
| * | | 2:30 PM | vs. | Davenport University | W-2-1 | stats | | 49-31-1 27-12 | Details |
| | | 3:00 PM | vs. | McKendree University | W-3-0 | stats | | 50-31-1 | Details |
| | Lindenwood Classic - St. Charles, Mo. |
| * | 21 | 4:00 PM | vs. | Indiana Institute of Technology | W-5-1 | stats | | 51-31-1 28-12 | Details |
| * | | 7:00 PM | vs. | University of Michigan-Dearborn | W-3-0 | stats | | 52-31-1 29-12 | Details |
| * | 22 | 4:00 PM | vs. | Indiana Institute of Technology | W-2-0 | stats | | 53-31-1 30-12 | Details |
| * | 23 | 7:00 PM | vs. | Siena Heights University | W-3-0 | stats | | 54-31-1 31-12 | Details |
| | 24 | 3:30 PM | vs. | Walsh University | W-3-0 | stats | | 55-31-1 | Details |
| | Walsh #25 in NAIA Poll, MU #7 | MU Crusader Classic - Livonia, Mich. |
| | | 7:00 PM | vs. | Berry College | W-3-0 | stats | | 56-31-1 | Details |
| | MU Crusader Classic - Livonia, Mich. |
| | 25 | | @ | TBA | L-21-24 | stats | | 56-32-1 | Details |
| | NAIA Great Lakes Invite (Grand Rapids, Mich.) |
| | | | @ | TBA | L-14-23 | stats | | 56-33-1 | Details |
| | NAIA Great Lakes Invite (Grand Rapids) |
| | | 9:30 AM | vs. | Trinity International University | W-3-1 | stats | | 57-33-1 | Details |
| | MU Crusader Classic - Livonia, Mich. |
| * | | 12:30 PM | @ | Siena Heights University | W-3-2 | stats | | 58-33-1 32-12 | Details |
| | | 1:30 PM | vs. | Taylor University | W-3-2 | stats | | 59-33-1 | Details |
| | TU #21 in NAIA Poll, MU #7 | MU Crusader Classic - Livonia, Mich. |
| * | | 3:00 PM | @ | Siena Heights University | W-2-1 (2OT) | stats | | 60-33-1 33-12 | Details |
| | 28 | 4:00 PM | vs. | Calvin College | L-1-2 | stats | | 60-34-1 | Details |
| * | | 7:00 PM | @ | Cornerstone University | W-3-0 | stats | | 61-34-1 34-12 | Details |
| | 29 | 4:00 PM | @ | Saginaw Valley State University | W-4-0 | stats | | 62-34-1 | Details |
| | 30 | 6:30 PM | @ | Webber International | L-2-3 | stats | | 62-35-1 | Details |
| | 31 | | vs. | Lindsey Wilson | L-59-70 | stats | | 62-36-1 | Details |
| | Taylor University Invite - Upland, Ind. - Oct. 31-Nov.1 |
| November |
| | 1 | | @ | Taylor University | L-58-59 | stats | | 62-37-1 | Details |
| | TU No. 16 in NAIA DII Poll | Taylor University Invite - Upland, Ind. - Oct. 31-Nov.1 |
| * | | 12:00 PM | vs. | Cornerstone University | W-4-1 | stats | | 63-37-1 35-12 | Details |
| * | | 2:30 PM | vs. | Cornerstone University | W-1-0 | stats | | 64-37-1 36-12 | Details |
| | 3 | 7:30 PM | vs. | St. Francis | L-66-89 | stats | | 64-38-1 | Details |
| * | 4 | 7:00 PM | vs. | Indiana Institute of Technology | W-3-1 | stats | | 65-38-1 37-12 | Details |
| | MU No. 10, IIT No. 19 in NAIA Poll |
| | 5 | 7:30 PM | vs. | Bethel College | L-64-65 | stats | | 65-39-1 | Details |
| | WHAC/MCC Challenge - Livonia, Mich. |
| * | 6 | 7:00 PM | @ | Davenport University | W-3-1 | stats | | 66-39-1 38-12 | Details |
| | | 7:00 PM | @ | Indiana University-South Bend | L-47-57 | stats | | 66-40-1 | Details |
| | 7 | 2:00 PM | vs. | Cornerstone University | W-2-0 | stats | | 67-40-1 | Details |
| | WHAC Semi-finals |
| * | | 7:00 PM | @ | Indiana Institute of Technology | L-1-3 | stats | | 67-41-1 38-13 | Details |
| | 8 | 11:00 AM | @ | TBA | L-6-7 | stats | | 67-42-1 | Details |
| | WHAC Championship (Hosted by Aquinas) |
| | | 11:00 AM | @ | TBA | L-4-6 | stats | | 67-43-1 | Details |
| | WHAC Championship (Hosted by Aquinas) |
| | | 1:00 PM | vs. | Siena Heights University | W-3-2 (2OT) | stats | | 68-43-1 | Details |
| | WHAC Semi-finals |
| | | 5:00 PM | vs. | Rochester College | W-80-44 | stats | | 69-43-1 | Details |
| | 11 | 8:00 PM | @ | Spring Arbor University | L-65-77 | stats | | 69-44-1 | Details |
| | Game can be heard live on MadonnaCrusaders.com |
| | 14 | 2:00 PM | vs. | Siena Heights University | L-1-2 (2OT) | stats | | 69-45-1 | Details |
| | WHAC Championship - SHU wins WHAC Championship |
| | | 6:00 PM | vs. | Aquinas College | W-3-1 | stats | | 70-45-1 | Details |
| | WHAC Semi-Finals at Indiana Tech |
| | | 8:00 PM | vs. | Shawnee State University | L-66-83 | stats | | 70-46-1 | Details |
| | Shawnee State Tournament - Shawnee, Ohio - Nov. 14-15 |
| | 15 | 1:00 PM | vs. | Cedarville University | L-65-81 | stats | | 70-47-1 | Details |
| | Shawnee State Tournament - Shawnee, Ohio - Nov.14-15 |
| | | 1:00 PM | vs. | Aquinas College | W-2-0 | stats | | 71-47-1 | Details |
| | WHAC Championship - at Churchill HS |
| | | 1:00 PM | @ | Indiana Institute of Technology | W-3-1 | stats | | 72-47-1 | Details |
| | WHAC Championship |
| | | 7:00 PM | vs. | Calvin College | L-49-64 | stats | | 72-48-1 | Details |
| | 18 | 6:00 PM | @ | Northwood University | L-70-106 | stats | | 72-49-1 | Details |
| | 21 | 7:00 PM | vs. | Indiana Wesleyan University | W-76-66 | stats | | 73-49-1 | Details |
| | IWU No. 8 in NAIA Poll | WHAC/MCC Challenge - Livonia, Mich. |
| | 22 | 1:00 PM | vs. | Grand View University | W-2-1 | stats | | 74-49-1 | Details |
| | NAIA Men's Soccer National Tournament Opening Round Match |
| | | 2:00 PM | @ | Eastern Michigan University | L-38-92 | stats | | 74-50-1 | Details |
| | | 3:00 PM | vs. | Defiance College | L-67-78 | stats | | 74-51-1 | Details |
| | Albion Tournament - Albion, Mich. - Nov. 22-23 |
| | 23 | 3:00 PM | @ | Albion College | L-64-77 | stats | | 74-52-1 | Details |
| | Albion Tournament - Albion, Mich. - Nov. 22-23 |
| | 25 | 7:00 PM | vs. | Wayne State University | L-35-61 | stats | | 74-53-1 | Details |
| | | 7:30 PM | @ | Rochester College | L-49-78 | | | 74-54-1 | Details |
| | Game played at Rochester HS |
| December |
| | 1 | 2:30 PM | vs. | University of Rio Grande | L-1-2 | stats | | 74-55-1 | Details |
| | NAIA Men's Soccer National Tournament Second Round Match |
| | | 7:00 PM | @ | Northwood University | L-47-80 | stats | | 74-56-1 | Details |
| | 2 | 7:00 PM | vs. | Lewis-Clark State College | L-2-3 | stats | | 74-57-1 | Details |
| | NAIA National Championship - Sioux City, Iowa |
| | 3 | 7:00 PM | vs. | Lubbock Christian | L-2-3 | stats | | 74-58-1 | Details |
| | NAIA National Championship - Sioux City, Iowa |
| | 4 | 7:00 PM | vs. | Biola University | L-1-3 | stats | | 74-59-1 | Details |
| | NAIA National Championship - Sioux City, Iowa |
| | 5 | 6:00 PM | vs. | Olivet College | L-66-70 | stats | | 74-60-1 | Details |
| | WHAC/MIAA Challenge - Alma, Mich. - Dec. 5-6 |
| | 6 | 8:00 PM | @ | Alma College | W-71-61 | stats | | 75-60-1 | Details |
| | WHAC/MIAA Challenge - Alma, Mich. - Dec. 5-6 |
| | 10 | 7:00 PM | @ | Marygrove College | W-78-60 | stats | | 76-60-1 | Details |
| | Game played at the University of Detroit Jesuit HS Arena |
| | 12 | 8:00 PM | vs. | Holy Cross | W-73-44 | stats | | 77-60-1 | Details |
| | Mich. Educational Credit Union Tournament - Livonia, Mich. - Dec. 12-13 |
| | 13 | 2:00 PM | vs. | Taylor University-Ft. Wayne | W-70-57 | stats | | 78-60-1 | Details |
| | Mich. Educational Credit Union Tournament - Liovnia, Mich. - Dec. 12-13 |
| | 16 | 5:30 PM | vs. | Cedarville University | L-54-84 | stats | | 78-61-1 | Details |
| | Cedarville ranked No. 18 in Div. II poll |
| | 17 | 7:00 PM | @ | Notre Dame College | W-63-60 | stats | | 79-61-1 | Details |
| | 18 | 7:00 PM | @ | Olivet College | W-77-68 | stats | | 80-61-1 | Details |
| | 28 | 9:00 PM | vs. | Vanguard University | L-59-84 | stats | | 80-62-1 | Details |
| | Las Vegas Shootout - Las Vegas, Nev. | Vanguard No. 2 in NAIA Div. I poll |
| | 29 | 3:00 PM | vs. | University of Great Falls | L-66-76 | stats | | 80-63-1 | Details |
| | Las Vegas Shootout - Las Vegas, Nev. |
| | | 6:00 PM | vs. | Judson University | L-83-87 | stats | | 80-64-1 | Details |
| | Hope College Tournament - Holland, Mich. |
| | 30 | 3:00 PM | vs. | California State University-Maritime | W-78-56 | stats | | 81-64-1 | Details |
| | Las Vegas Shootout - Las Vegas, Nev. |
| | | 6:00 PM | vs. | Davenport University | W-74-68 | stats | | 82-64-1 | Details |
| | Hope College Tournament |
| January |
| | 3 | 3:00 PM | @ | Marygrove College | W-84-63 | stats | | 83-64-1 | Details |
| | Game played at the University of Detroit Jesuit HS Arena |
| * | 7 | 7:30 PM | @ | Indiana Institute of Technology | W-61-51 | stats | | 84-64-1 39-13 | Details |
| * | | 7:30 PM | vs. | Indiana Institute of Technology | L-74-77 | stats | | 84-65-1 39-14 | Details |
| * | 10 | 1:00 PM | @ | Cornerstone University | L-63-65 | stats | | 84-66-1 39-15 | Details |
| * | | 3:00 PM | vs. | Cornerstone University | W-75-68 | stats | | 85-66-1 40-15 | Details |
| * | 14 | 7:30 PM | vs. | Siena Heights University | W-68-61 | stats | | 86-66-1 41-15 | Details |
| * | | 7:30 PM | @ | Siena Heights University | L-65-68 | stats | | 86-67-1 41-16 | Details |
| * | 17 | 1:00 PM | vs. | Aquinas College | L-58-65 | stats | | 86-68-1 41-17 | Details |
| * | | 3:00 PM | vs. | Aquinas College | L-61-68 | stats | | 86-69-1 41-18 | Details |
| * | 21 | 7:30 PM | vs. | Concordia University | W-66-53 | stats | | 87-69-1 42-18 | Details |
| * | | 7:30 PM | @ | Concordia University | W-62-43 | stats | | 88-69-1 43-18 | Details |
| * | 24 | 1:00 PM | vs. | Davenport University | L-72-74 | stats | | 88-70-1 43-19 | Details |
| * | | 3:00 PM | @ | Davenport University | L-54-66 | stats | | 88-71-1 43-20 | Details |
| * | 28 | 5:30 PM | @ | University of Michigan-Dearborn | W-73-66 | stats | | 89-71-1 44-20 | Details |
| * | | 7:30 PM | @ | University of Michigan-Dearborn | W-72-53 | stats | | 90-71-1 45-20 | Details |
| * | 31 | 1:00 PM | vs. | Indiana Institute of Technology | W-61-40 | stats | | 91-71-1 46-20 | Details |
| * | | 3:00 PM | @ | Indiana Institute of Technology | L-84-95 | stats | | 91-72-1 46-21 | Details |
| February |
| * | 4 | 7:30 PM | vs. | Cornerstone University | L-57-72 | stats | | 91-73-1 46-22 | Details |
| * | | 7:30 PM | @ | Cornerstone University | L-45-76 | stats | | 91-74-1 46-23 | Details |
| * | 7 | 3:00 PM | @ | Siena Heights University | W-65-52 | stats | | 92-74-1 47-23 | Details |
| * | | 3:00 PM | vs. | Siena Heights University | W-76-73 (OT) | stats | | 93-74-1 48-23 | Details |
| * | 11 | 6:00 PM | @ | Aquinas College | W-52-38 | stats | | 94-74-1 49-23 | Details |
| | Madonna Upsets #23 Aquinas |
| * | | 8:00 PM | @ | Aquinas College | L-40-63 | stats | | 94-75-1 49-24 | Details |
| | #25 Aquinas defeats Madonna |
| * | 14 | 1:00 PM | vs. | Concordia University | W-75-57 | stats | | 95-75-1 50-24 | Details |
| * | | 3:00 PM | @ | Concordia University | W-75-72 | stats | | 96-75-1 51-24 | Details |
| * | 18 | 7:30 PM | @ | Davenport University | L-67-82 | stats | | 96-76-1 51-25 | Details |
| * | | 7:30 PM | vs. | Davenport University | W-72-63 | stats | | 97-76-1 52-25 | Details |
| * | 21 | 1:00 PM | vs. | University of Michigan-Dearborn | W-57-55 | stats | | 98-76-1 53-25 | Details |
| * | | 3:00 PM | vs. | University of Michigan-Dearborn | L-52-56 | stats | | 98-77-1 53-26 | Details |
| | 25 | 7:30 PM | vs. | Siena Heights University | W-79-72 | stats | | 99-77-1 | Details |
| | WHAC Tournament Quarterfinals |
| | 26 | 7:30 PM | @ | Indiana Institute of Technology | L-61-70 | stats | | 99-78-1 | Details |
| | WHAC Tournament Quarterfinal |
| | 27 | 10:30 AM | vs. | Lewis University | W-10-4 | stats | | 100-78-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | 28 | 1:00 PM | @ | Davenport University | L-73-85 | stats | | 100-79-1 | Details |
| | WHAC Tournament Semi-Final |
| | | 3:30 PM | vs. | Point Loma Nazarene University | W-1-0 | stats | | 101-79-1 | Details |
| | PLNU No. 2 in NAIA Poll - Tucson Invitational (Tucson, Ariz.) |
| | | 5:30 PM | vs. | Hope International University | W-9-1 (6) | stats | | 102-79-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| March |
| | 1 | 12:30 PM | vs. | William Penn University | L-0-4 | stats | | 102-80-1 | Details |
| | RussMatt Invitational - Lake Myrtle Park - Auburndale, Fla. |
| | | Game 2 | vs. | William Penn University | W-3-1 | stats | | 103-80-1 | Details |
| | | 3:30 PM | vs. | Iowa Wesleyan College | W-12-2 (5) | stats | | 104-80-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | | 5:30 PM | vs. | Hope International University | W-11-3 (6) | stats | | 105-80-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | 2 | 1:00 PM | vs. | Viterbo University | W-3-2 | stats | | 106-80-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | | 3:00 PM | @ | Warner University | W-9-4 | stats | | 107-80-1 | Details |
| | RussMatt Invitational - Royals Baseball Field - Lake Wales, Fla. |
| | | 5:30 PM | vs. | Concordia Illinois | W-8-0 (5) | stats | | 108-80-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | 3 | 12:30 PM | vs. | Evangel University | W-7-1 | stats | | 109-80-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | | Game 2 | vs. | Evangel University | W-8-6 | stats | | 110-80-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | 4 | 11:00 AM | vs. | Iowa Wesleyan College | W-9-1 (6) | stats | | 111-80-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | | 12:30 PM | vs. | Notre Dame College | W-7-6 | stats | | 112-80-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | | 1:00 PM | vs. | DeSales University | L-1-2 | stats | | 112-81-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | | Game 2 | vs. | Notre Dame College | W-8-6 | stats | | 113-81-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | 5 | 9:00 AM | vs. | Point Park University | W-9-8 (10) | stats | | 114-81-1 | Details |
| | RussMatt Invitational - Disney Hess Complex - Kissimmee, Fla. |
| | | 11:00 AM | vs. | DeSales University | W-6-1 | stats | | 115-81-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | | 1:00 PM | vs. | Viterbo University | W-8-2 | stats | | 116-81-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | 6 | | vs. | Point Park University | W-10-0 (5) | stats | | 117-81-1 | Details |
| | RussMatt Invitational - Disney Hess Complex - Kissimmee, Fla. |
| | | 3:30 PM | vs. | Simon Fraser University | L-1-2 | stats | | 117-82-1 | Details |
| | | 5:30 PM | vs. | Purdue University-North Central | W-3-2 | stats | | 118-82-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | 7 | 9:00 AM | vs. | William Penn University | W-2-0 | stats | | 119-82-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | | 11:00 AM | vs. | University of Great Falls | W-5-2 | stats | | 120-82-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | | Game 2 | vs. | William Penn University | W-8-7 | stats | | 121-82-1 | Details |
| | RussMatt Invitational - Chain of Lakes Park - Winter Haven, Fla. |
| | | 1:00 PM | vs. | Trinity International University | W-11-0 | stats | | 122-82-1 | Details |
| | Tucson Invitational (Tucson, Ariz.) |
| | 8 | 2:30 PM | vs. | Mount Marty College | W-4-0 | stats | | 123-82-1 | Details |
| | RussMatt Invitational - Lake Myrtle Park - Auburndale, Fla. |
| | | Game 2 | vs. | Mount Marty College | L-0-1 (8) | stats | | 123-83-1 | Details |
| | RussMatt Invitational - Lake Myrtle Park - Auburndale, Fla. |
| | 13 | 5:00 PM | @ | Spalding University | W-12-6 | stats | | 124-83-1 | Details |
| | 14 | 12:00 PM | @ | Spalding University | W-13-2 (7) | stats | | 125-83-1 | Details |
| | | 1:00 PM | vs. | Bethel College | L-4-6 | stats | | 125-84-1 | Details |
| | | Game 2 | vs. | Bethel College | L-3-9 | stats | | 125-85-1 | Details |
| | 15 | 12:00 PM | vs. | Berea College | W-12-2 | stats | | 126-85-1 | Details |
| | Game played at Spalding University |
| | 17 | 2:00 PM | vs. | University of Saint Francis | W-21-16 | stats | | 127-85-1 | Details |
| | | Game 2 | vs. | University of Saint Francis | W-8-7 | stats | | 128-85-1 | Details |
| | 19 | 3:00 PM | @ | Indiana University Southeast | W-9-0 (5) | stats | | 129-85-1 | Details |
| | MU's Jess Irwin throws third career no hitter |
| | | Game 2 | @ | Indiana University Southeast | W-8-1 | stats | | 130-85-1 | Details |
| | 20 | 12:00 PM | @ | College of the Ozarks | W-10-2 | stats | | 131-85-1 | Details |
| | | 1:00 PM | vs. | Trevecca Nazarene University | W-4-1 | stats | | 132-85-1 | Details |
| | Campbellsville University/Lindsey Wilson Classic |
| | | Game 2 | vs. | Trevecca Nazarene University | W-6-1 | stats | | 133-85-1 | Details |
| | Campbellsville University/Lindsey Wilson Classic |
| | | 5:00 PM | vs. | Missouri Baptist College | W-13-3 | stats | | 134-85-1 | Details |
| | Played at College of the Ozarks |
| | 21 | 9:30 AM | vs. | Martin Methodist | L-0-7 | stats | | 134-86-1 | Details |
| | MMC No. 13 in NAIA Poll | Campbellsville University/Lindsey Wilson Classic |
| | | 11:00 AM | vs. | Missouri Baptist College | RAIN | | | | Details |
| | Played at College of the Ozarks |
| | | 4:00 PM | @ | College of the Ozarks | RAIN | | | | Details |
| | | 4:15 PM | vs. | Union College | W-4-1 | stats | | 135-86-1 | Details |
| | Campbellsville University/Lindsey Wilson Classic |
| | 22 | 10:00 AM | @ | Campbellsville University | L-1-2 | stats | | 135-87-1 | Details |
| | Campbellsville University/Lindsey Wilson Classic |
| | | 12:00 PM | vs. | UVA-Wise | W-1-0 | stats | | 136-87-1 | Details |
| | | 3:00 PM | @ | College of the Ozarks | W-16-0 (5) | stats | | 137-87-1 | Details |
| | | Game 2 | @ | College of the Ozarks | W-14-7 | stats | | 138-87-1 | Details |
| | 25 | 4:00 PM | vs. | Rochester College | W-12-0 (5) | stats | | 139-87-1 | Details |
| | | Game 2 | vs. | Rochester College | W-8-0 | stats | | 140-87-1 | Details |
| | 28 | Game 2 | vs. | Huntington University | W-2-0 | stats | | 141-87-1 | Details |
| | | 1:00 PM | vs. | Huntington University | W-5-0 | stats | | 142-87-1 | Details |
| * | | 1:00 PM | vs. | Davenport University | W-5-0 | stats | | 143-87-1 54-26 | Details |
| * | | Game 2 | vs. | Davenport University | L-2-4 | stats | | 143-88-1 54-27 | Details |
| | 30 | 9:30 AM | @ | TBA | L-4-5 | stats | | 143-89-1 | Details |
| | Bellarmine Invitational (Hosted by Bellarmine University - Persimmon Ridge GC - Louisville, Ky.) |
| | 31 | 9:30 AM | @ | TBA | L-4-5 | stats | | 143-90-1 | Details |
| | Bellarmine Invitational (Hosted by Bellarmine University - Persimmon Ridge GC - Louisville, Ky.) |
| * | | 1:00 PM | vs. | Davenport University | W-9-4 | stats - recap | | 144-90-1 55-27 | Details |
| * | | Game 2 | vs. | Davenport University | W-2-1 | stats | | 145-90-1 56-27 | Details |
| April |
| * | 1 | 4:00 PM | vs. | University of Michigan-Dearborn | W-8-0 (5) | stats - recap | | 146-90-1 57-27 | Details |
| * | | Game 2 | vs. | University of Michigan-Dearborn | W-9-1 (6) | stats | | 147-90-1 58-27 | Details |
| | 3 | 10:00 AM | @ | TBA | L-2-9 | stats - recap | | 147-91-1 | Details |
| | Purple and White Invitational (Hosted by Capital University - Foxfire Country Club - Grove City, Ohio) |
| * | | 4:00 PM | vs. | Concordia University | W-5-1 | stats | | 148-91-1 59-27 | Details |
| * | | Game 2 | vs. | Concordia University | W-5-1 | stats | | 149-91-1 60-27 | Details |
| | 4 | 10:00 AM | @ | TBA | L-1-9 | stats | | 149-92-1 | Details |
| | Purple and White Invitational (Hosted by Capital University - Players Country Club - Grove City, Ohio) |
| | | 12:00 PM | @ | TBA | L-5-11 | stats | | 149-93-1 | Details |
| | Trine University Spring Invitational (Hosted by Trine University - Zollner Golf Course - Angola, Ind.) |
| * | | 1:00 PM | vs. | Indiana Institute of Technology | W-3-2 | stats | | 150-93-1 61-27 | Details |
| * | | Game 2 | vs. | Indiana Institute of Technology | W-3-1 | stats | | 151-93-1 62-27 | Details |
| * | | 1:00 PM | @ | Davenport University | W-8-0 (6) | stats | | 152-93-1 63-27 | Details |
| * | | Game 2 | @ | Davenport University | W-3-0 | stats | | 153-93-1 64-27 | Details |
| | 5 | | @ | TBA | L-4-11 | stats - recap | | 153-94-1 | Details |
| | Trine University Spring Invitational (Hosted by Trine University - Zollner Golf Course - Angola, Ind.) |
| * | | 1:00 PM | vs. | Indiana Institute of Technology | W-7-1 | stats - recap | | 154-94-1 65-27 | Details |
| * | | Game 2 | vs. | Indiana Institute of Technology | W-8-0 | stats | | 155-94-1 66-27 | Details |
| * | 8 | 3:00 PM | @ | Indiana Institute of Technology | L-4-7 | stats | | 155-95-1 66-28 | Details |
| * | | Game 2 | @ | Indiana Institute of Technology | W-16-7 | stats - recap | | 156-95-1 67-28 | Details |
| * | 9 | 4:00 PM | @ | Concordia University | W-7-0 | stats | | 157-95-1 68-28 | Details |
| * | | Game 2 | @ | Concordia University | W-3-1 | stats - recap | | 158-95-1 69-28 | Details |
| * | 10 | 4:00 PM | @ | Aquinas College | W-7-4 | stats | | 159-95-1 70-28 | Details |
| * | | Game 2 | @ | Aquinas College | L-0-8 (6) | stats | | 159-96-1 70-29 | Details |
| | 11 | 9:00 AM | @ | TBA | L-1-8 | recap | | 159-97-1 | Details |
| | Glen Oaks College Spring Invitational (Hosted by Glen Oaks College - Golf Club of Coldwater - Coldwater, Mich.) |
| * | | 1:00 PM | vs. | Siena Heights University | W-8-5 | stats - recap | | 160-97-1 71-29 | Details |
| * | | Game 2 | vs. | Siena Heights University | L-5-6 | stats | | 160-98-1 71-30 | Details |
| * | | 1:00 PM | @ | Cornerstone University | W-8-0 (5) | stats - recap | | 161-98-1 72-30 | Details |
| | Jess Irwin throws second perfect game in MU history |
| * | | Game 2 | @ | Cornerstone University | W-10-1 (6) | stats | | 162-98-1 73-30 | Details |
| * | 13 | 1:00 PM | @ | Siena Heights University | RAIN | | | | Details |
| * | | Game 2 | @ | Siena Heights University | RAIN | | | | Details |
| | 14 | | vs. | TBA | W-4-2 | stats - recap | | 163-98-1 | Details |
| | Madonna University Crusader Invitational (Hosted by Madonna University - Walnut Creek Country Club - South Lyon, Mich.) |
| | | 4:00 PM | vs. | Spring Arbor University | RAIN | | | | Details |
| * | | 4:00 PM | vs. | Siena Heights University | RAIN | | | | Details |
| * | | Game 2 | vs. | Siena Heights University | RAIN | | | | Details |
| | 15 | 10:00 AM | vs. | TBA | W-4-2 | stats - recap | | 164-98-1 | Details |
| | Madonna University Crusader Invitational (Hosted by Madonna University - Walnut Creek Country Club - South Lyon, Mich.) |
| * | | 1:00 PM | @ | Siena Heights University | RAIN | | | | Details |
| * | | Game 2 | @ | Siena Heights University | RAIN | | | | Details |
| * | | 4:00 PM | vs. | University of Michigan-Dearborn | W-8-0 (5) | stats - recap | | 165-98-1 74-30 | Details |
| * | | Game 2 | vs. | University of Michigan-Dearborn | W-8-3 | stats | | 166-98-1 75-30 | Details |
| * | 16 | 1:00 PM | @ | Siena Heights University | L-1-2 | stats | | 166-99-1 75-31 | Details |
| * | | Game 2 | @ | Siena Heights University | W-12-2 | stats - recap | | 167-99-1 76-31 | Details |
| | 17 | 11:00 AM | @ | TBA | L-6-12 | stats - recap | | 167-100-1 | Details |
| | Bill Gettig Trine Invitational (Hosted by Trine University - Zollner Golf Course - Angola, Ind.) |
| * | | 4:30 PM | @ | Siena Heights University | W-8-0 (6) | stats - recap | | 168-100-1 77-31 | Details |
| | J. Irwin breaks her own single-season strike out record (277) |
| * | | Game 2 | @ | Siena Heights University | W-5-2 | stats | | 169-100-1 78-31 | Details |
| | 18 | 11:00 AM | @ | TBA | L-2-12 | stats - recap | | 169-101-1 | Details |
| | Bill Gettig Trine Invitational (Hosted by Trine University - Zollner Golf Course - Angola, Ind.) |
| * | | 1:00 PM | @ | Concordia University | W-11-0 | stats - recap | | 170-101-1 79-31 | Details |
| * | | Game 2 | @ | Concordia University | W-11-3 | stats | | 171-101-1 80-31 | Details |
| * | | 1:00 PM | @ | Indiana Institute of Technology | W-2-1 | stats - recap | | 172-101-1 81-31 | Details |
| * | | Game 2 | @ | Indiana Institute of Technology | W-2-1 (8) | stats | | 173-101-1 82-31 | Details |
| * | 19 | 1:00 PM | vs. | Davenport University | L-2-3 (8) | stats | | 173-102-1 82-32 | Details |
| * | | Game 2 | vs. | Davenport University | W-5-3 | stats - recap | | 174-102-1 83-32 | Details |
| * | | 1:00 PM | vs. | Concordia University | W-3-1 | stats - recap | | 175-102-1 84-32 | Details |
| * | | Game 2 | vs. | Concordia University | W-5-1 | stats | | 176-102-1 85-32 | Details |
| | 23 | 9:00 AM | @ | TBA | L-3-9 | stats - recap | | 176-103-1 | Details |
| | Spring Arbor Invitational (hosted by Spring Arbor - Arbor Hill GC - Spring Arbor, Mich.) |
| * | | 4:00 PM | vs. | Siena Heights University | W-7-1 | stats - recap | | 177-103-1 86-32 | Details |
| * | | Game 2 | vs. | Siena Heights University | W-8-0 (6) | stats | | 178-103-1 87-32 | Details |
| * | 24 | 1:30 PM | @ | Aquinas College | W-11-4 | stats - recap | | 179-103-1 88-32 | Details |
| * | | 4:00 PM | vs. | Cornerstone University | W-4-3 | stats - recap | | 180-103-1 89-32 | Details |
| * | | Game 2 | vs. | Cornerstone University | W-11-3 (6) | stats | | 181-103-1 90-32 | Details |
| * | | Game 2 | @ | Aquinas College | L-7-8 | stats | | 181-104-1 90-33 | Details |
| * | 25 | 1:00 PM | vs. | Aquinas College | L-8-9 (9) | stats | | 181-105-1 90-34 | Details |
| * | | Game 2 | vs. | Aquinas College | W-10-3 (5) | stats - recap | | 182-105-1 91-34 | Details |
| * | | 1:00 PM | vs. | Aquinas College | W-3-1 | stats | | 183-105-1 92-34 | Details |
| * | | Game 2 | vs. | Aquinas College | L-1-5 | stats | | 183-106-1 92-35 | Details |
| | 28 | 4:30 PM | vs. | Spring Arbor University | RAIN | | | | Details |
| | 30 | 10:00 AM | vs. | Siena Heights University | RAIN | | | | Details |
| | WHAC Tournament |
| | | 4:00 PM | vs. | WHAC Playoffs | RAIN | | | | Details |
| | WHAC Tournament |
| May |
| | 1 | 12:00 PM | vs. | Siena Heights University | W-10-1 (5) | stats | | 184-106-1 | Details |
| | Continuation of 4/30 game delayed by rain |
| | | 2:00 PM | vs. | Davenport University | W-12-0 (5) | stats - recap | | 185-106-1 | Details |
| | WHAC Tournament |
| | | 4:00 PM | vs. | Concordia University | L-6-13 | stats - recap | | 185-107-1 | Details |
| | WHAC Tournament |
| | 2 | 10:00 AM | vs. | Siena Heights University | W-11-1 | stats | | 186-107-1 | Details |
| | WHAC Tournament |
| | | 3:00 PM | vs. | Davenport University | W-29-7 | stats - recap | | 187-107-1 | Details |
| | WHAC Tournament |
| | 3 | 12:00 PM | vs. | Concordia University | W-13-4 | stats - recap | | 188-107-1 | Details |
| | WHAC Tournament |
| | | 3:30 PM | vs. | Indiana Institute of Technology | L-7-11 | stats | | 188-108-1 | Details |
| | 4 | 10:00 AM | vs. | University of Michigan-Dearborn | W-4-3 | stats | | 189-108-1 | Details |
| | WHAC Tournament |
| | | 3:00 PM | vs. | Aquinas College | L-2-3 | stats | | 189-109-1 | Details |
| | WHAC Tournament |
| | | 6:15 PM | vs. | Aquinas College | W-11-3 (5) | stats - recap | | 190-109-1 | Details |
| | WHAC Championship Game |
| | 12 | 2:00 PM | vs. | Fresno Pacific University | W-12-11 (12) | stats - recap | | 191-109-1 | Details |
| | NAIA Baseball National Championship Opening Round - Sioux City, Iowa |
| | 13 | 2:00 PM | vs. | Bellevue University | L-4-18 | stats - recap | | 191-110-1 | Details |
| | NAIA Baseball National Championship Opening Round - Sioux City, Iowa |
| | 14 | 1:00 PM | vs. | Fresno Pacific University | L-2-6 | stats - recap | | 191-111-1 | Details |
| | NAIA Baseball National Championship Opening Round - Sioux City, Iowa |
| | | 3:30 PM | vs. | McKendree University | W-3-1 | stats - recap | | 192-111-1 | Details |
| | NAIA National Championship - Decatur, Ala. |
| | 15 | 7:00 PM | vs. | Holy Names College | W-3-0 | stats - recap | | 193-111-1 | Details |
| | NAIA National Championship - Decatur, Ala. |
| | 16 | 4:30 PM | vs. | Point Loma Nazarene University | PPD | | | | Details |
| | Game PPD in top of 2nd inning due to rain - NAIA National Championship - Decatur, Ala. |
| | 17 | 4:00 PM | vs. | Point Loma Nazarene University | L-1-8 | stats - recap | | 193-112-1 | Details |
| | NAIA National Championship - Decatur, Ala. |
